Decoding Cellular Longevity Through Science
Discover how PCC1 extends lifespan by targeting cellular senescence. Research from 199 Biotechnologies reveals the longevity blueprint through advanced senolytic compounds.
Selectively eliminates senescent cells through apoptosis. PCC1's senolytic properties make it a powerful life extension compound in the longevity blueprint.
Beyond senolytic activity, PCC1 exhibits senomorphic properties, modifying SASP to reduce inflammation and support healthy aging pathways.
Research by 199 Biotechnologies shows PCC1 extended median lifespan by 64.2% in aged models, demonstrating powerful longevity supplement potential.
Cellular senescence drives aging. Senolytic compounds like Procyanidin C1 represent the future of life extension science.
Senescent cells accumulate with age, secreting inflammatory factors that damage surrounding tissues. This cellular senescence accelerates aging and age-related diseases.
Procyanidin C1 acts as a targeted senolytic, clearing damaged cells while preserving healthy ones. This selective action is key to effective life extension strategies.
Stay informed about senolytic research, life extension studies, and longevity supplement developments from 199 Biotechnologies.
Single-cell analysis revealing PCC1's broad geroprotective effects on hematopoietic and immune systems through senolytic and senomorphic mechanisms.
Aging-related skin fibrosis (SF) is a complex condition with limited treatment options. Procyanidin C1 (PCC1), a natural polyphenolic compound with demonstrated senolytic activity, has emerged as a potential therapeutic agent for fibrotic disorders throu …
Latest research demonstrating PCC1's senolytic role in alleviating renal fibrosis by specifically targeting senescent renal tubular epithelial cells.
Demonstrates PCC1's protective effects against intervertebral disc degeneration through SIRT3/FOXO3-mediated mitochondrial dynamics regulation.
Shows PCC1's ability to improve lung fibrosis by promoting apoptosis in senescent myofibroblasts, providing therapeutic approach for pulmonary fibrosis treatment.
Demonstrates PCC1's senolytic and senomorphic properties in ameliorating age-related retinal impairment through comprehensive single-cell RNA sequencing analysis of retinal landscape changes.
Recent PNAS study demonstrates that PCC1 can rejuvenate retinal function by targeting senescent cells in the retina, showing potential benefits for age-related vision decline.
Demonstrates procyanidin's protective effects against ferroptosis and inflammation through Nrf2/HO-1 pathway modulation.
Shows procyanidin C1's anti-colon cancer effects through modulation of miR-501-3p/HIGD1A axis, inhibiting tumor growth and metastasis.
Comprehensive review of procyanidin C1 and other procyanidins' effects on gut health and microbiota interactions.
Optimizes extraction of procyanidins including PCC1 from coffee pulp using novel hybrid microwave-ultrasound extraction method.
An in-depth look at the unique trimeric structure of PCC1 composed of flavan-3-ol subunits and how it contributes to its biological activity.
Get the latest senolytic research, life extension insights, and longevity blueprint updates from 199 Biotechnologies.
Led by Boris Djordjevic and the 199 Longevity Clinic team